Oferty pracy w projektach finansowanych przez NCN


Narodowe Centrum Nauki prezentuje bazę ogłoszeń o wolnych stanowiskach pracy przy projektach finansowanych przez Centrum. Narodowe Centrum Nauki nie ponosi odpowiedzialności za treść i wiarygodność przesyłanych ofert pracy.

Uprzejmie informujemy o nowych warunkach zatrudniania osób na stanowiska typu post-doc: limit czasu upływającego od uzyskania stopnia doktora dla aplikujących na te stanowiska kobiet może być przedłużony o 1,5 roku za każde urodzone bądź przysposobione dziecko.

Oferta pracy

Nazwa jednostki: Centre of New Technologies of the University of WarszawaWarszawa, Inne oferty z tego miasta »
Nazwa stanowiska: PhD student in Laboratory of the Molecular Biology of Cancer
Wymagania:

• MSc in biology or related fields or MD,
• Good knowledge of English,
• Experience or knowledge in laboratory work: gel electrophoresis, PCR, RT-PCR, q-PCR, DNA/RNA/Protein extraction and purification, DNA cloning, lentiviruses, western blot, cryo- and paraffin- sectioning, immunofluorescent and immunohistochemistry staining, microscopy: fluorescent and confocal laser scanning microscopy, mammalian cell culture, FACS sorting, laboratory animals
- mice handling, xenograft model, valid mouse handling certificate
• Knowledge of Adobe Photoshop, Adobe Illustrator, PowerPoint,
• Team work skills.

Opis zadań:

Title of the project:
Role of catulin in the regulation of cell-extracellular matrix interactions in tumor invasion and metastasis of head and neck squamous cell carcinoma.
Leader:
Agnieszka Kobielak
Project description:
Head and neck squamous cell carcinoma (HNSCC) is highly aggressive tumor and despite various treatment options available, HNSCC patients are still faced with a high chance of recurrence and/or metastasis, with a 5-year survival rate of only about 50 percent. Thus understanding the metastatic process is of high importance and is highly significant for the development of novel treatments. Abnormal cell migration and invasion modulated by integrin-mediated interactions between the extracellular matrix (ECM) and the actin cytoskeleton are key components of metastasis. We recently identified that high expression of Rho-GEF binding protein α-catulin correlates with the ability of human squamous cell carcinoma cells to invade and metastasize. We showed that α-Catulin is preferentially expressed at the tumor invasion front and in the invasive streams of cells with minimal expression in the normal oral epithelia. Our in vitro data show that an upregulation of α-catulin expression correlates with the transition of tumor cells from an epithelial to mesenchymal morphology and knockdown of α-catulin in hHNSCC cell lines dramatically decreases the migratory and invasive potential of those cells in vitro and metastatic potential in xenotransplants in vivo. α-catulin deficient cells exhibit defects in actin dynamics, Rho signaling and directional migration. Performed by us transcriptional and biochemical analyses of tumors deficient in α-catulin demonstrate that its ablation prevent tumor cells from invading the surrounding stroma which is accompanied by changes in expression of genes involved in cell migration and invasion. The main goal of the project is to understand molecular mechanism of signal transduction by the catulin-Rho/ROCK downstream from integrins in metastasizing squamous cell carcinoma cells in order to identify novel strategies for HNSCC treatments and prevent cancer cell metastasis.
Responsibilities:
Participation in all research planned in the project

Typ konkursu NCN: OPUS – NZ
Termin składania ofert: 31 marca 2019, 23:59
Forma składania ofert: email
Warunki zatrudnienia:

Stimulating work environment in friendly group of researcher

Dodatkowe informacje:

Requiered documents:
• Curriculum Vitae (CV)
• Cover letter, describing Candidate motivation
• MSc certificate
• One or more letters of recommendation from a scientist who is familiar with the Candidate (submitted directly to email address below)
• Information on scientific publications, scholarships, prizes and awards or other relevant documents demonstrating the excellence of Candidate
• A list of attended conferences with titles and authors of presentations
• A personal data processing agreement

Application procedure:
Please apply to: a.kobielak@cent.uw.edu.pl (entitle your email “PhD POSITION”).

Contract duration:
36 months
Salary:
4000 PLN gross/month
Position:
PhD Student
Employment starts:
01.05.2019

Data dodania ogłoszenia: 2019-03-15 17:25:47

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